p53调控骨关节炎软骨细胞凋亡

肿瘤抑制蛋白p53是一种可以有效调节哺乳动物细胞生长的核磷酸化蛋白质。p53表达增加能够激活一系列细胞基因,通过抑制多个细胞周期蛋白依赖性激酶导致细胞周期停滞并凋亡。有研究表明,骨关节炎(osteoarthritis,OA)软骨细胞中,p53的表达高于正常软骨细胞,通过下调p53表达能够减少软骨细胞凋亡,进而预防和缓解骨关节炎病变,这可能与线粒体凋亡途径密切相关,但是具体机制尚不明确。本文通过综述近年来p53调控骨关节炎软骨细胞凋亡的文献资料,为骨关节炎机制和治疗有关研究提供理论基础。

p53 Regulates Chondrocyte Apoptosis in Osteoarthritis

The tumor suppressor protein p53 is a nuclear phosphoprotein that potently regulates the growth of mammalian cells. The increased expression of p53 activates a series of genes, resulting in cell cycle arrest and apoptosis by inhibiting multiple cyclin-dependent kinases. Some studies have shown that the expression of p53 in chondrocytes of osteoarthritis (OA) is higher than that in normal chondrocytes. Down-regulation of p53 expression reduces the apoptosis of chondrocytes and prevent and alleviate OA lesions, which may be closely related to mitochondrial apoptosis pathways, but the specific mechanism remains unclear. This article reviews the literature about p53-regulated chondrocyte apoptosis in OA in recent years, and provides a further basis for OA pathogenesis and treatment research.