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Enzymatic Baeyer–Villiger oxidation of steroids with cyclopentadecanone monooxygenase |
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| Authors: | Elisa Beneventi Gianluca Ottolina Giacomo Carrea Walter Panzeri Giovanni Fronza Peter C.K. Lau |
| Affiliation: | aIstituto di Chimica del Riconoscimento Molecolare, Consiglio Nazionale delle Ricerche (CNR), Via Mario Bianco 9, 20131 Milano, Italy;bIstituto di Chimica del Riconoscimento Molecolare, CNR, Via Mancinelli 7, Milano, Italy;cBiotechnology Research Institute, NRC, Montreal, Quebec H4P 2R2, Canada |
| Abstract: | Recombinant cyclopentadecanone monooxygenase from Pseudomonas sp. catalyzed the preparative-scale Baeyer–Villiger oxidation of numerous 3 and 17-ketosteroids with a full control of the regiochemistry of the produced lactones. The recovered product yields were up to 42%. |
| Keywords: | Baeyer– Villiger oxidation Biocatalysis Monooxygenase Steroids |
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