首页 | 本学科首页   官方微博 | 高级检索  
     


Doxorubicin affects actin assembly in vitro
Authors:R Colombo  A Necco  G Vailati  B Saracco  A Milzani  G Scarì
Affiliation:1. Dept. of Biology, University of Milano Via Celoria, 26 — 20133 Milano, Italy;2. Dept. of Biology — Lab. of Electron Microscopy Via Celoria, 26 — 20133 Milano, Italy;3. Research and Development Dept. Farmitalia Carlo Erba Via C. Imbonati, 24 — 20159 Milano, Italy;1. Department of Biochemistry, Faculty of Life Sciences, Aligarh Muslim University, Aligarh 202002, India;2. Interdisciplinary Biotechnology Unit, Aligarh Muslim University, Aligarh 202002, India;1. Department of Chemistry, Indian Institute of Technology, Kharagpur, Kharagpur 721302, India;2. Department of Physics, Indian Institute of Technology, Kharagpur, Kharagpur 721302, India;3. Institute of Molecular Pharmacology, Research Centre for Natural Sciences, Hungarian Academy of Sciences, 1025 Pusztaszeriút 59-67, Budapest, Hungary;1. Interdisciplinary Biotechnology Unit, Aligarh Muslim University, Aligarh 202002, India;2. Advanced Instrumentation Research Facility (AIRF), Jawaharlal Nehru University, New Delhi 110067, India;1. Molecular Biophysics and Biophysical Chemistry Group, Interdisciplinary Biotechnology Unit, Aligarh Muslim University, Aligarh, 202002, India;2. Laboratory of Cancer Epigenetics, Division of Endocrinology, CSIR-Central Drug Research Institute, Lucknow, India;3. Center for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi, India;1. Interdisciplinary Biotechnology Unit, Aligarh Muslim University, Aligarh 202002, India;2. Surfactant Research Chair, Department of Chemistry, King Saud University, College of Science, P.O. Box-2455, Riyadh 11451, Saudi Arabia;3. Laboratory of Immunology and Molecular Physiology, Zoology Department, Faculty of Science, Assiut University, Assiut 71516, Egypt;1. Interdisciplinary Biotechnology Unit, Aligarh Muslim University, Aligarh, 202002, Uttar Pradesh, India;2. Molecular Biology Department, Genetic Engineering and Biotechnology Division, National Research Centre, Dokki, Cairo, Egypt
Abstract:In vitro experiments on actin polymerization in the presence of doxorubicin show that the rate of salt-induced actin assembly is negatively affected by the drug. The decreased amount of actin monomers keeping their ability to self-interact to give F actin (microfilaments) probably explains the reduction of assembly value. Drug action is dose-dependent and various discrepancies are explained by the limitations of the techniques used.
Keywords:
本文献已被 ScienceDirect PubMed 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号