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肿瘤细胞的自噬和窖蛋白-1
引用本文:刘艳,王洋,史丹,邹伟. 肿瘤细胞的自噬和窖蛋白-1[J]. 生物工程学报, 2012, 28(8): 912-917
作者姓名:刘艳  王洋  史丹  邹伟
作者单位:1. 辽宁师范大学生命科学学院,辽宁大连,116081
2. 辽宁师范大学生命科学学院,辽宁大连116081;辽宁省生物技术与分子药物研发重点实验室,辽宁大连116081
基金项目:国家自然科学基金 (Nos. 30570225, 30970353) 资助。
摘    要:自噬作用是一种细胞通过溶酶体自我降解的过程,在肿瘤的形成和发展中起着双重作用。窖蛋白-1(Caveolin-1,Cav-1)作为胞膜窖的标志蛋白,介导许多生理和病理过程,包括胞膜窖的形成、膜泡运输、维持细胞胆固醇稳态、信号转导和肿瘤的发生。近年来,许多研究表明肿瘤细胞自噬和Cav-1存在一定关系。文中就近年来肿瘤细胞的自噬与Cav-1的关系及其在肿瘤发生和发展过程中的作用进行综述。

关 键 词:自噬  肿瘤  Caveolin-1  缺氧诱导因子1α  核因子κB
收稿时间:2012-12-18

Autophagy and Caveolin-1 in cancer: a review
Yan Liu,Yang Wang,Dan Shi and Wei Zou. Autophagy and Caveolin-1 in cancer: a review[J]. Chinese journal of biotechnology, 2012, 28(8): 912-917
Authors:Yan Liu  Yang Wang  Dan Shi  Wei Zou
Affiliation:College of Life Sciences, Liaoning Normal University, Dalian 116021, Liaoning, China;College of Life Sciences, Liaoning Normal University, Dalian 116021, Liaoning, China;College of Life Sciences, Liaoning Normal University, Dalian 116021, Liaoning, China;College of Life Sciences, Liaoning Normal University, Dalian 116021, Liaoning, China;Liaoning Key Laboratories of Biotechnology and Molecular Drug Research and Development, Dalian 116021, Liaoning, China
Abstract:Autophagy, is an essential cellular process involving self-degradation of intracellular components via the lysosome, which plays the Janus role in cancer initiation and progression. Caveolin-1, a marker protein of caveolae, functions as scaffolding protein mediating many physiological and pathological processes including caveolae biogenensis, vesicular transport, cholesterol homeostasis, signal transduction and tumorigenesis. Recently, many reports showed that autophagy of tumor cells associated with stromal Cav-1. In this article, we reviewed the role of autophagy and relationship with Cav-1 in tumorigenesis and cancer development.
Keywords:autophagy  tumor  Caveolin-1  hypoxia inducible factor-1α  nuclear factor κB
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