Anorexigen-induced pulmonary hypertension and the serotonin (5-HT) hypothesis: lessons for the future in pathogenesis |
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Authors: | Saadia Eddahibi and Serge Adnot |
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Institution: | (1) INSERM U492, D?partement de Physiologie, H?pital H. Mondor, Cr?teil, France; |
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Abstract: | Epidemiological studies have established that fenfluramine, D-fenfluramine, and aminorex, but not other appetite suppressants,
increase the risk of primary pulmonary hypertension (PH). One current hypothesis suggests that fenfluramine-like medications
may act through interactions with the serotonin (5-hydroxytryptamine 5-HT]) transporter (5-HTT) located on pulmonary artery
smooth muscle cells and responsible for the mitogenic action of 5-HT. Anorexigens may contribute to PH by boosting 5-HT levels
in the bloodstream, directly stimulating smooth muscle cell growth, or altering 5-HTT expression. We suggest that individuals
with a high basal level of 5-HTT expression related to the presence of the long 5-HTT gene promoter variant may be particularly
susceptible to one or more of these potential mechanisms of appetite-suppressant-related PH. |
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Keywords: | |
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