7,8-Benzoflavone stimulates the metabolic activation of aflatoxin B1 to mutagens by human liver. |
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| Authors: | M K Buening J G Fortner A Kappas A H Corney |
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| Institution: | 1. Department of Biochemistry and Drug Metabolism, Hoffmann-La Roche Inc., Nutley, New Jersey 07110 USA;2. Memorial Sloan-Kettering Cancer Center, New York, New York 10021 USA;3. The Rockefeller University, New York, New York 10021 USA |
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| Abstract: | The addition of 7,8-benzoflavone to a monooxygenase system from human liver markedly stimulated the metabolic activation of aflatoxin B1 to mutagens. When 7,8-benzoflavone (5 × 10?5M) was added to this monooxygenase system, the amount of aflatoxin B1 needed for a mutagenic response was decreased by 20- to 40-fold. 7,8-Benzoflavone did not stimulate the metabolic activation of aflatoxin B1 to mutagens when rat liver was used as a source of monooxygenase. |
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