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Potent 4-amino-5-azaindole factor VIIa inhibitors |
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| Authors: | Hu Huiyong Kolesnikov Aleksandr Riggs Jennifer R Wesson Kieron E Stephens Robin Leahy Ellen M Shrader William D Sprengeler Paul A Green Michael J Sanford Ellen Nguyen Margaret Gjerstad Erik Cabuslay Ronnel Young Wendy B |
| Institution: | Celera Genomics, South San Francisco, CA 94080, USA. huiyong.hu@yahoo.com |
| Abstract: | The 4-amino-5-azaindole as an amidino-benzimidazole replacement is described. A series of potent and selective analogs were discovered and showed desirable ex vivo efficacy as measured by PT. |
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