Isolation and characterization of a novel postsynaptic/cytotoxic neurotoxin from Daboia russelli russelli venom. |
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| Authors: | R R J Shelke S Sathish T V Gowda |
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| Affiliation: | Biochemistry of Aging Laboratory, College of Health and Human Performance, Gainesville, FL 3211-8205, USA. shelker@ufl.edu |
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| Abstract: | A postsynaptic neurotoxin was purified from Daboia russelli russelli venom using gel filtration, ion-exchange chromatography and reverse-phase high-performance liquid chromatography. The N-terminal sequence, molecular mass and pharmacological activities of the neurotoxin/cytotoxin indicate that it is a short-chain neurotoxin like that found in Elapid venom. This is the first report on the presence of such a postsynaptic neurotoxin from D. r. russelli venom. |
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