The role of Islet Neogenesis-Associated Protein (INGAP) in islet neogenesis |
| |
| Authors: | Mark Lipsett Stephen Hanley Mauro Castellarin Emily Austin Wilma L Suarez-Pinzon Alex Rabinovitch Lawrence Rosenberg |
| |
| Institution: | (1) Department of Surgery, McGill University, Montreal, Quebec, Canada, H3G 1A4;(2) Centre for Pancreatic Diseases, Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada, H3G 1A4;(3) Muttart Diabetes Research Centre, University of Alberta, Edmonton, Alberta, Canada, T6G 2S2 |
| |
| Abstract: | Islet Neogenesis-Associated Protein (INGAP) is a member of the Reg family of proteins implicated in various settings of endogenous
pancreatic regeneration. The expression of INGAP and other RegIII proteins has also been linked temporally and spatially with
the induction of islet neogenesis in animal models of disease and regeneration. Furthermore, administration of a peptide fragment
of INGAP (INGAP peptide) has been demonstrated to reverse chemically induced diabetes as well as improve glycemic control
and survival in an animal model of type 1 diabetes. Cultured human pancreatic tissue has also been shown to be responsive
to INGAP peptide, producing islet-like structures with function, architecture and gene expression matching that of freshly
isolated islets. Likewise, studies in normoglycemic animals show evidence of islet neogenesis. Finally, recent clinical studies
suggest an effect of INGAP peptide to improve insulin production in type 1 diabetes and glycemic control in type 2 diabetes.
Mark Lipsett and Stephen Hanley contributed equally. |
| |
| Keywords: | INGAP Islet neogenesis Pancreatic plasticity Regeneration Diabetes |
| 本文献已被 PubMed SpringerLink 等数据库收录！ |
|
