| 合欢皮中抗肿瘤新生血管高效低毒组分的筛选及药效学研究 |
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| 引用本文： | 易清清,刘玲艳,冯磊,邱丽颖.合欢皮中抗肿瘤新生血管高效低毒组分的筛选及药效学研究[J].天然产物研究与开发,2013,25(8):1046-1051. |
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| 作者姓名： | 易清清 刘玲艳 冯磊 邱丽颖 |
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| 作者单位： | 江南大学药学院,无锡,214122 |
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| 摘 要： | 从合欢皮中提取分离组分1~24,SRB法测定IC50,LDH试剂盒评价毒性,筛选出乙醇回流正丁醇萃取的组分23为抗肿瘤新生血管高效低毒组分,化学定性其主要成分为皂苷,HMEC-1细胞上的IC50为4.18±0.37μg·mL-1,LDH阳性药物浓度为40μg·mL-1。细胞迁移、成管实验表明组分23对细胞迁移、成管均有抑制作用。急性毒性实验测得最小致毒量和最小致死量分别为100 mg·kg-1,4000 mg·kg-1。建立肿瘤小鼠模型进行组分23的体内药效学研究:中剂量4 mg·(kg·d)-1,高剂量组8 mg·(kg·d)-1CD31蛋白标志肿瘤血管数明显降低,低剂量2 mg·(kg·d)-1、中剂量、高剂量组肿瘤细胞凋亡数目显著增高。
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| 关 键 词： | 合欢皮 抗肿瘤新生血管 高效低毒组分 药效学研究 |
Screening and Pharmacodynamic Study of High-efficiency and Low-toxicity Component on the Anti-angiogenic Effect from Albizia julibrissin |
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| YI Qing-qing
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LIU Ling-yan
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FENG Lei
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QIU Li-ying.Screening and Pharmacodynamic Study of High-efficiency and Low-toxicity Component on the Anti-angiogenic Effect from Albizia julibrissin[J].Natural Product Research and Development,2013,25(8):1046-1051. |
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| Authors: | YI Qing-qing LIU Ling-yan FENG Lei QIU Li-ying |
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| Institution: | YI Qing-qing;LIU Ling-yan;FENG Lei;QIU Li-ying;School of medicine,Jiangnan University; |
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| Abstract: | |
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| Keywords: | Albizia julibrissin anti-angiogenesis high-efficiency and low-toxicity components pharmacodynamic study |
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