Helical crystals of sickle cell hemoglobin |
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Authors: | Thomas E Wellems Robert Josephs |
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Institution: | Department of Biophysics and Theoretical Biology The University of Chicago 920 East 58th Street Chicago, Ill. 60637, U.S.A. |
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Abstract: | Thin ribbon-like crystals are intermediates in the formation of large crystals of deoxyhemoglobin S from many individual fibers. The thin crystals show foldedover regions when observed by electron microscopy. Some crystals are sufficiently long to have several folds each separated by a distance of about 4.4 μm, suggesting that the crystals are helical in solution. The thickness of the crystals varies from 500 to 900 Å as shown by heavy-metal shadowing and by measurements of the thickness at the crossover point where an edge-on view of the crystal is obtained. |
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