Steroid 6 beta-hydroxylase and 6-desaturase reactions catalyzed by adrenocortical mitochondrial P-450. |
| |
| Authors: | H Mochizuki K Suhara M Katagiri |
| |
| Affiliation: | Department of Chemistry, Faculty of Science, Kanazawa University, Japan. |
| |
| Abstract: | The minor steroid hydroxylase activity of purified bovine adrenocortical mitochondrial P-450 is described. The results indicate that both P-450scc and P-450(11 beta) act on deoxycorticosterone and androstenedione to form 6 beta-hydroxydeoxycorticosterone and 6 beta-hydroxyandrostenedione (6 beta-hydroxylase), respectively. Both forms of P-450 also catalyze 6-desaturation of androstenedione to form 4,6-androstadiene-3,17-dione (6-desaturase). |
| |
| Keywords: | |
|
|
