Use of controlled-release polymer to feed ammonium to Streptomyces clavuligerus cephalosporin fermentations in shake flasks |
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| Authors: | C Lübbe A L Demain K Bergman |
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| Institution: | (1) Fermentation Microbiology Laboratory, Department of Applied Biological Sciences, Massachusetts Institute of Technology, 02139 Cambridge, MA, USA;(2) Present address: Fermentation Process Development, Pharmaceutical Research Division, Schering-Plough, 07083 Union, NJ, USA;(3) Present address: Department of Biology, Northeastern University, 02115 Boston, MA, USA |
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| Abstract: | Summary Controlled-release polymers containing NH4Cl were used to feed NH
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to Streptomyces clavuligerus cultures making cephalosporins in shake flasks. Production was improved in comparison to free NH4Cl included in the medium at various concentrations; it approached the performance of l-asparagine, the best single nitrogen source for production. |
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