Phosphate directed Y-M variation in candida albicans

Summary The influence of pH, O-R potential, dextrose/inorganic phosphate ratio, nitrogen source, and various cations on filamentation ofCandida albicans when grown on phosphate enriched Sabouraud Dextrose Agar (Difco) at 37° C were investigated. The dextrose/phosphate ratio apparently plays a key role under these conditions. It is postulated that magnesium ion trapped within the cell by excess polyphosphate formation leads to filamentation.Supported by U.S.P.H.S. E-1700 and U.N.C. Research Council 324-ALU-1 (360).