Nucleotide sequence divergence and functional constraint in VIP precursor mRNA evolution between human and rat |
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| Authors: | M Nishizawa Y Hayakawa N Yanaihara H Okamoto |
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| Affiliation: | 1. Department of Biochemistry, Toyama Medical and Pharmaceutical University School of Medicine, Toyama 930-01, Japan;2. Laboratory of Bioorganic Chemistry, Shizuoka College of Pharmacy, Shizuoka 422, Japan;3. Department of Biochemistry, Tohoku University School of Medicine, Sendai 980, Miyagi, Japan |
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| Abstract: | The nucleotide sequence analysis of cloned cDNA for VIP precursor from rat cerebral cortex reveals that the precursor contains both rat VIP and PHI-27. The deduced primary structure of rat VIP is identical with human VIP. The amino acid sequence of rat PHI-27 differs by 4 amino acids from human PHM-27. When each VIP precursor is divided functionally into 6 domains, the amino acid sequence homology between rat and human precursors ranges from 69 to 100%. In contrast, any domain exhibits an essentially equal degree of nucleotide sequence homology. |
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