New approach to 3-oxo-4-aza-5alpha-androst-1-ene-17beta-(N-tert-butylcarboxamide) |
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| Authors: | Jiang Zhong-Xing Ye Jing-Quan Jiang Li Zhao Ying-Sheng |
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| Affiliation: | College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, Hubei, PR China. ioc@whu.edu.cn |
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| Abstract: | We describe the synthesis of 3-oxo-4-aza-5alpha-androst-1-ene-17beta-(N-tert-butylcarboxamide) (finasteride) from 4-androstene-3,17-dione (AD) in seven steps in an overall yield of 18.6% via oxidation, ammoniumation, dehydration, and dehydrogenation. |
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| Keywords: | Steroid 4-Androstene-3,17-dione Finasteride Synthesis |
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