| HCV复合多表位抗原基因表达及免疫原性的研究 |
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| 引用本文： | 黄建生,解咏梅,林元凯,任大明.HCV复合多表位抗原基因表达及免疫原性的研究[J].微生物学报,1999,39(3):268-271. |
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| 作者姓名： | 黄建生 解咏梅 林元凯 任大明 |
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| 作者单位： | 复旦大学遗传学研究所遗传工程国家重点实验室 |
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| 摘 要： | 分类号Ｑ７８１文献标识码Ａ文章编号０００１６２０９（１９９９）０３０２６８７１丙型肝炎是常见的传染病之一，易于慢性化及发展为肝硬化，且与肝癌的发生关系密切，目前尚无理想的防治手段。国内外对丙型肝炎疫苗的研究仍处于克隆表达ＨＣＶ部分基因产物或合成…
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| 关 键 词： | 丙型肝炎病毒（HCV） 多表位抗原基因 T／B细胞表位 表达 |
Expression of a HCV multi-epitopes antigen gene and study on its immunogenicity] |
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| J Huang,Y Xie,Y Lin,S Ke,D Ren.Expression of a HCV multi-epitopes antigen gene and study on its immunogenicity][J].Acta Microbiologica Sinica,1999,39(3):268-271. |
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| Authors: | J Huang Y Xie Y Lin S Ke D Ren |
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| Institution: | State Key Laboratory, Institute of Genetics, Fudan University, Shanghai 200433. |
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| Abstract: | Due to the hypervariable character of hepatitis C virus (HCV), 5 conserved T and/or B cell epitopes from core, envelope, NS3 and NS5 protein of HCV were chosen to form a 270 bp multi-epitopes antigen gene. The gene was clone into a fusion vector pWR450-1 to express a beta-galactosidase-HCV hybrid protein GZ-PCX. The purified GZ-PCX protein was specifically recognized by human anti-HCV antibodies. These results show that the HCV hybrid multi-epitopes antigen has excellent immunogenicity, which might be able to be used as an effective diagnosis agent and to provide protectivity to any genotype of HCV which might partly solve the problems in the researches of HCV vaccines. |
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