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Isolation of a human-like antibody fragment (scFv) that neutralizes ricin biological activity

Authors:	Thibaut Pelat Michael Hust Martha Hale Marie-Paule Lefranc Stefan Dübel and Philippe Thullier

Institution:	(1) Groupe de biotechnologie des anticorps, D?partement de biologie des agents transmissibles, Centre de Recherche du Service de Sant? des Arm?es, La Tronche, France;(2) Institut f?r Biochemie und Biotechnologie, Technische Universit?t Braunschweig, Braunschweig, Germany;(3) Integrated Toxicology, United States Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Frederick, MD, USA;(4) IMGT, Laboratoire d'ImmunoG?n?tique Mol?culaire, LIGM, Universit? Montpellier 2, UPR CNRS 1142, Institut de G?n?tique Humaine, IGH, Montpellier, France, and Institut Universitaire de France, Paris, France

Abstract:	Background Ricin is a lethal toxin that inhibits protein synthesis. It is easily extracted from a ubiquitously grown plant, Ricinus communis, and thus readily available for use as a bioweapon (BW). Anti-ricin antibodies provide the only known therapeutic against ricin intoxication.

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