Molecular events leading to the creation of a pandemic influenza virus |
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Authors: | Shipra Sharma Adarsh Mayank Sunil K Lal |
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Institution: | (1) Department of Virology, Hygiene Institute, University of Heidelberg, Im Neuenheimer Feld 324, 69120 Heidelberg, Germany; |
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Abstract: | Influenza A virus is a potent pathogen of annual respiratory illness with huge potential of causing occasional pandemics of
catastrophic consequences. In April 2009, a novel, swine-origin influenza A H1N1/09 virus was identified in Mexico which continued
to spread globally. This unique virus emerged from an avian, human, Eurasian swine viral strain and a North American swine
strain belonging to the lineage of the 1930 swine virus. Till date H1N1/09 pandemic has been relatively mild and lacks the
previously described molecular markers of influenza A pathogenicity and transmissibility. In this review, we will discuss
the molecular and antigenic determinants of this virus and its designation as a low pathogenic strain, which carries the potential
to develop into a devastating strain with subsequent mutations and reassortments. |
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Keywords: | H1N1 Pandemic Antigenic determinants Pathogenicity |
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