Association of the Late Cornified Envelope-3 Genes with Psoriasis and Psoriatic Arthritis:A Systematic Review |
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| Authors: | Changbing Shen Jing Gao Xianyong Yin Yujun Sheng Liangdan Sun Yong Cui Xuejun Zhang Institute and |
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| Affiliation: | Changbing Shen;Jing Gao;Xianyong Yin;Yujun Sheng;Liangdan Sun;Yong Cui;Xuejun Zhang;Institute and Department of Dermatology,The First Affiliated Hospital,Anhui Medical University;The Key Laboratory of Dermatology,Ministry of Education,Anhui Medical University;Collaborative Innovation Center for Complex and Severe Dermatosis;Department of Dermatology,The Second Affiliated Hospital,Anhui Medical University; |
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| Abstract: | Psoriasis(Ps)and psoriatic arthritis(Ps A)are genetically complex diseases with strong genetic evidence.Recently,susceptibility genes for Ps and Ps A have been identified within the late cornified envelop(LCE)gene cluster,especially the cluster 3(LCE3)genes.It is noteworthy that the deletion of LCE3B and LCE3C(LCE3C_LCE3B-del)is significantly associated with these two diseases.Gene-gene interactions between LCE3 genes and other genes are associated with Ps and Ps A.LCE3 genes also have pleiotropic effect on some autoimmune diseases,such as rheumatoid arthritis,atopic dermatitis and systemic lupus erythematosus.Further studies need to focus on the potential function of LCE3 genes in the pathogenesis of Ps and Ps A in the future. |
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