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Conicamin, a novel histamine antagonist from the mediterranean tunicate Aplidium conicum |
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| Authors: | Aiello Anna Borrelli Francesca Capasso Raffaele Fattorusso Ernesto Luciano Paolo Menna Marialuisa |
| Institution: | a Dipartimento di Chimica delle Sostanze Naturali, via D. Montesano, 49, I-80131, Napoli, Italy b Dipartimento di Farmacologia Sperimentale, via D. Montesano, 49, I-80131, Napoli, Italy |
| Abstract: | In addition to the known 6-bromo-hypaphorine (2) and plakohypaphorine-A (3), the methanol extract of the Mediterranean tunicate Aplidium conicum was shown to contain conicamin, a novel indole alkaloid having histamine-antagonistic activity which structure was determined to be 1 on the basis of the spectral data. |
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