A new meiosis-specific cohesin complex implicated in the cohesin code for homologous pairing |
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| Authors: | Ishiguro Kei-ichiro Kim Jihye Fujiyama-Nakamura Sally Kato Shigeaki Watanabe Yoshinori |
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| Institution: | 1Laboratory of Chromosome Dynamics, Institute of Molecular and Cellular Biosciences, University of Tokyo, 1-1-1 Yayoi, Tokyo 113-0032, Japan;2Laboratory of Nuclear Signaling, Institute of Molecular and Cellular Biosciences, and University of Tokyo, 1-1-1 Yayoi, Tokyo 113-0032, Japan;3Graduate School of Agricultural and Life Science, University of Tokyo, 1-1-1 Yayoi, Tokyo 113-0032, Japan |
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| Abstract: | We identify a new mammalian cohesin subunit, RAD21-like protein (RAD21L), with sequence similarity to RAD21 and REC8. RAD21L localizes along axial elements in early meiotic prophase, in a manner that is spatiotemporally different to either REC8 or RAD21. Remarkably, RAD21L and REC8 have symmetrical, mutually exclusive localization on the not-yet-synapsed homologues, implying that the cohesin patterning could provide a code for homologue recognition. RAD21 transiently localizes to axial elements after the dissociation of RAD21L and REC8 in late pachytene, a period of recombination repair. Further, we show that the removal of cohesins and synaptonemal complex during late meiotic prophase is promoted by Polo-like kinase 1, which is similar to the mitotic prophase pathway. |
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| Keywords: | cohesin meiosis chromosome segregation homologue synapsis centromere |
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