Immune response to the mumps component of the MMR vaccine in the routine
of immunisation services in the Brazilian National Immunisation
Program |
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Authors: | Eliane Matos dos Santos Gloria Regina da Silva e Sá Marilda Mendon?a Siqueira Reinaldo de Menezes Martins Luiz Antonio Bastos Camacho Vanessa dos Reis von Doellinger Maria de Lourdes de Sousa Maia |
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Institution: | 1. Unidade de Assessoria Clínica, Bio-Manguinhos, Instituto Oswaldo Cruz, Rio de Janeiro, RJ, Brasil;2. Laboratório de Vírus Respiratórios e Sarampo, Instituto Oswaldo Cruz, Rio de Janeiro, RJ, Brasil;3. Escola Nacional de Saúde Pública-Fiocruz, Rio de Janeiro, RJ, Brasil |
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Abstract: | A non-controlled longitudinal study was conducted to evaluate the combined vaccine
against measles, mumps and rubella (MMR) immunogenicity in 150 children vaccinated in
the routine of three health units in the city of Rio de Janeiro, Brazil, 2008-2009,
without other vaccines administered during the period from 30 days before to 30 days
after vaccination. A previous study conducted in Brazil in 2007, in 1,769 children
ranging from 12-15 months of age vaccinated against yellow fever and MMR
simultaneously or at intervals of 30 days or more between doses, had shown low
seroconversion for mumps regardless of the interval between administration of the two
vaccines. The current study showed 89.5% (95% confidence interval: 83.3; 94.0)
seroconversion rate for mumps. All children seroconverted for measles and rubella.
After revaccination, high antibody titres and seroconversion rates were achieved
against mumps. The results of this study and others suggest that two MMR doses confer
optimal immunoresponses for all three antigens and the possible need for additional
doses should be studied taking into account not only serological, but also
epidemiological data, as there is no serological correlate of protection for
mumps. |
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Keywords: | MMR vaccine immunogenicity mumps |
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