Differential increase in topoisomerase II in simian virus 40-infected cells. |
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| Authors: | R Rainwater and K Mann |
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| Affiliation: | Biology Department, University of Alaska, Anchorage 99508. |
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| Abstract: | The time course of expression of topoisomerase I, topoisomerase II, and simian virus 40 (SV40) large tumor (T) antigen was determined in whole-cell extracts of uninfected versus SV40-infected TC7 cells. After a minor increase, the level of topoisomerase I remained fairly constant throughout the time course in both uninfected and SV40-infected cells. In contrast, the level of topoisomerase II increased markedly in SV40-infected cells but not in uninfected cells following the appearance of SV40 T antigen. |
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