Deficiency in mouse Y chromosome long arm gene complement is associated with sperm DNA damage |
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| Authors: | Yasuhiro Yamauchi Jonathan M Riel Zoia Stoytcheva Paul S Burgoyne Monika A Ward |
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| Institution: | (1) Institute for Biogenesis Research, John A Burns School of Medicine, University of Hawaii, 1960 East-West Rd, Honolulu, HI 96822, USA;(2) Division of Developmental Genetics, MRC National Institute for Medical Research, Mill Hill, London, NW, 7 1AA, UK |
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| Abstract: | Background Mice with severe non-PAR Y chromosome long arm (NPYq) deficiencies are infertile in vivo and in vitro. We have previously shown that sperm from these males, although having grossly malformed heads, were able to fertilize oocytes
via intracytoplasmic sperm injection (ICSI) and yield live offspring. However, in continuing ICSI trials we noted a reduced
efficiency when cryopreserved sperm were used and with epididymal sperm as compared to testicular sperm. In the present study
we tested if NPYq deficiency is associated with sperm DNA damage - a known cause of poor ICSI success. |
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