| 国产胸腺肽治疗慢性乙肝疗效及其机理初探 |
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| 引用本文： | 陈国良,欧阳丽娟,吴晓鹭.国产胸腺肽治疗慢性乙肝疗效及其机理初探[J].中国微生态学杂志,1999,11(5):290-291. |
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| 作者姓名： | 陈国良 欧阳丽娟 吴晓鹭 |
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| 作者单位： | 厦门市中医院传染科!361002(陈国良，欧阳丽娟，吴晓鹭)，厦门大学肿瘤细胞工程专业实验室!361005(颜江华，宋思扬，苏文金) |
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| 摘 要： | 本文观察大剂量胸腺肽对慢性乙肝患者的治疗作用并研究其作用机理。用ＥＬＩＳＡ、ＰＣＲ 和免疫化学染色法等比较分析胸腺肽治疗三个月后，ＡＬＴ、ＨＢＶ－ Ｍ 和ＨＢＶ ＤＮＡ 等指标变化，发现患者ＡＬＴ 复常率、ＨＢｅＡｇ 转阴率、ＨＢＶ ＤＮＡ 阴转率和ＨＢＶ ＤＮＡ 有效下降率分别为５８．３３ ％ 、３３．３３ ％ 、４１．６７ ％ 和９１．６７ ％ ；同时患者外周血ＣＤ４ ＋淋巴细胞亚群上调，ＣＤ８ ＋ 亚群下调，二者比值趋于正常。说明国产胸腺肽治疗慢性乙肝有较好的应用前景，其治疗机理与免疫调节作用有关。
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| 关 键 词： | 胸腺肽 ALT HBVDNACD抗原 |
| 修稿时间： | 1998-08-12 |
CLINICAL TREATMENT OF
CHRONICAL HEPATITIS B BY
NATIONAL THYMOSIN AND ITS MECHANISM |
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| Traditional Chinese Medicine Hospital of Xiamen,Xiamen , Ceng Guoliang Ouyang Lijian Wu Xiaolu State Laboratory for Tumour Cell Engineering,Xiamen University,Xiamen Yan Jianghua Song siyang Su Wenjin.CLINICAL TREATMENT OF
CHRONICAL HEPATITIS B BY
NATIONAL THYMOSIN AND ITS MECHANISM[J].Chinese Journal of Microecology,1999,11(5):290-291. |
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| Authors: | Traditional Chinese Medicine Hospital of Xiamen Xiamen Ceng Guoliang Ouyang Lijian Wu Xiaolu State Laboratory for Tumour Cell Engineering Xiamen University Xiamen Yan Jianghua Song siyang Su Wenjin |
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| Institution: | Traditional Chinese Medicine Hospital of Xiamen,Xiamen 361002, Ceng Guoliang Ouyang Lijian 1 Wu Xiaolu 1 State Laboratory for Tumour Cell Engineering,Xiamen University,Xiamen 361005 Yan Jianghua 2 Song siyang 2 Su Wenjin 2 |
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| Abstract: | The purpose of this paper was to observe the effects of clinical treatment of chronic hepatitis B by national thymosin and study its machanisms The parameters of HBV-M,HBV DNA and CD-antigens of T cells were detected by ELISA,PCR and immunochemical dying assay after three months of the thymosin treatment The rates of normal-turning of ALT,negative-turning of HBeAg, negative-turning of HBV DNA, and effective downing of HBV DNA in patients with chronic hepatitis B were 58 33%, 33 33%, 41 67%,and 91 67%,respectively At the same time,T CD4 cells in the peripheral blood of patients was up-regulated,T CD8 was down-regulated;and ratio of CD4 /CD8 is tend to be normal These findings showed that thymosin had a proposing feature in the treatment of chronic hepatitis B and its mechanism may be related to immuno-regulation |
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| Keywords: | Thymosin\ ALT HBV DNA\ CD-antigen |
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