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Synthesis and evaluation of 1,5-diaryl-substituted tetrazoles as novel selective cyclooxygenase-2 (COX-2) inhibitors |
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| Authors: | Al-Hourani Baker Jawabrah Sharma Sai Kiran Mane Jonathan Y Tuszynski Jack Baracos Vickie Kniess Torsten Suresh Mavanur Pietzsch Jens Wuest Frank |
| Affiliation: | a Department of Oncology, University of Alberta, Edmonton, Canada b Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Canada c Institute of Radiopharmacy, Research Center Dresden-Rossendorf, Dresden, Germany |
| Abstract: | A series of 1,5-diaryl-substituted tetrazole derivatives was synthesized via conversion of readily available diaryl amides into corresponding imidoylchlorides followed by reaction with sodium azide. All compounds were evaluated by cyclooxygenase (COX) assays in vitro to determine COX-1 and COX-2 inhibitory potency and selectivity. Tetrazoles 3a-e showed IC50 values ranging from 0.42 to 8.1 mM for COX-1 and 2.0 to 200 μM for COX-2. Most potent compound 3c (IC50 (COX-2) = 2.0 μM) was further used in molecular modeling docking studies. |
| Keywords: | Cyclooxygenase COX-2 inhibitors 1,5-Diaryl-tetrazoles |
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