GTPase signaling: bridging the GAP between ARF and Rho |
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| Authors: | Santy Lorraine C Casanova James E |
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| Affiliation: | Department of Cell Biology, University of Virginia, Health Sciences Center, P.O. Box 800732, Charlottesville, Virginia 22908-0732, USA. |
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| Abstract: | Membrane traffic and actin cytoskeleton dynamics are intimately linked, and GTPases of the Rho and ARF families may work together to regulate both. Recent studies have identified a family of GTPase activating proteins (GAPs) that contain both ARF-GAP and Rho-GAP domains, providing the first direct link between these two signaling pathways. |
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