Apoptotic activities of C2-ceramide and C2-dihydroceramide homologues against HL-60 cells |
| |
Authors: | Shikata Keiji Niiro Hayato Azuma Hideki Ogino Kenji Tachibana Taro |
| |
Institution: | Department of Applied and Bioapplied Chemistry, Graduate School of Engineering, Osaka City University, Sugimoto 3-3-138, Sumiyoshi-ku, Osaka 558-8585, Japan. |
| |
Abstract: | The apoptotic activities of non-natural ceramide homologues, C2-homo-ceramide, C2-homo-dihydroceramide, C2-bishomo-ceramide and C2-bishomo-dihydroceramide, were examined using human leukemia HL-60 cells. The apoptotic activity was in order of C2-ceramide>C2-homo-ceramide approximately C2-bishomo-ceramide and the activities of the L-erythro- and D-erythro-ceramide homologues were similar. The morphological features of the cells, DNA fragmentations, proteolytic processing of pro-caspase-3 and the cleavage of PARP as the result of treatments with these homologues indicated that cell death was induced by apoptosis. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|