| Affiliation: | 1.The Linnaeus Centre for Bioinformatics,Uppsala University,Uppsala,Sweden;2.Dept. of Evolutionary Biology,University of Copenhagen,Copenhagen ?,Denmark;3.School of Computing Sciences,University of East Anglia,Norwich,UK |
| Abstract: | Background In the last few decades there has been a great deal of discussion concerning whether or not noncoding RNA sequences (ncRNAs) fold in a more well-defined manner than random sequences. In this paper, we investigate several existing measures for how well an RNA sequence folds, and compare the behaviour of these measures over a large range of Rfam ncRNA families. Such measures can be useful in, for example, identifying novel ncRNAs, and indicating the presence of alternate RNA foldings. |
