Evaluation of alginate compressed matrices as prolonged drug delivery systems |
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Authors: | Paolo Giunchedi Elisabetta Gavini Mario Domenico Luigi Moretti Gerolamo Pirisino |
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Institution: | (1) Dipartimento di Scienze del Farmaco, Universita’ di Sassari, via Muroni 23/A, Sassari, Italy |
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Abstract: | This research investigated the use of sodium alginate for the preparation of hydrophylic matrix tablets intended for prolonged
drug release using ketoprofen as a model drug. The matrix tablets were prepared by direct compression using sodium alginate,
calcium gluconate, and hydroxypropylmethylcellulose (HPMC) in different combinations and ratios. In vitro release tests and
erosion studies of the matrix tablets were carried out in USP phosphate buffer (pH 7.4). Matrices consisting of sodium alginate
alone or in combination with 10% and 20% of HPMC give a prolonged drug release at a fairly constant rate. Incorporation of
different ratios of calcium gluconate leads to an enhancement of the release rate from the matrices and to the loss of the
constant release rate of the drug. Only the matrices containing the highest quantity of HPMC (20%) maintained their capacity
to release ketoprofen for a prolonged time. |
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Keywords: | Sodium alginate Calcium gluconate Ionic interaction Prolonged release Hydrophilic matrix |
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