Comparative effects of growth inhibitors on sterol metabolism in the nematode Caenorhabditis elegans |
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| Affiliation: | 1. Insect Physiology Laboratory, ARS, USDA, Beltsville, MD 20705 USA;2. Department of Botany, University of Maryland, College Park, MD 20742, USA. Telephone: (301) 344-2389;1. Department of Pharmacognosy, Faculty of Pharmacy, Gazi University, Etiler 6330, Ankara, Turkey;2. Department of Pharmacognosy, Faculty of Pharmacy, Yüzüncü Yıl University, 65080, Van, Turkey;3. Department of Parasitology, Faculty of Veterinary Medicine, Afyon Kocatepe University, Afyon, Turkey;1. Department of Biotechnology, Thiagarajar College, Madurai, Tamil Nadu, India;2. NCoE – MHRD, Thiagarajar College, Madurai, Tamil Nadu, India;3. Department of Zoology, Government Arts and Science College, Melur, Tamil Nadu, India;4. Postgraduate & Research Department of Zoology, Arulmigu Palaniandavar College of Arts and Culture, Palani, Tamil Nadu, India;5. Department of Zoology and Microbiology, Thiagarajar College, Madurai, Tamil Nadu, India;6. Department of Zoology, University of Madras, Chennai - 25, Tamil Nadu, India;7. Plant Production Department, College of Food and Agricultural Sciences, King Saud University, P.O. Box. 2460, Riyadh 11451, Saudi Arabia;8. Botany and Microbiology Department, College of Science, King Saud University, P.O. Box. 2460, Riyadh 11451, Saudi Arabia;9. Mycology and Plant Disease Survey Department, Plant Pathology Research Institute, ARC, Giza 12511, Egypt;10. Department of Ecotoxicology & Genetic Toxicology, Ross Lifescience Pvt. Ltd., Pune, India;1. School of Traditional Chinese Medicine, Capital Medical University, Beijing 100069, China;2. State Key Laboratory Breeding Base of Dao-di Herbs, National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China;3. Beijing University of Chinese Medicine Third Affiliated Hospital, Beijing 100029, China |
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| Abstract: | 1. An analogous series of dimethylalkyl compounds, consisting of four amines, an amide, and a phosphonate ester, inhibited motility and reproduction of the nematode Caenorhabditis elegans.2. Dimethylamines with straight-chain lengths of 12, 14, or 16 carbon atoms were equally active nematicides, causing greater than 80% population growth inhibition at a concentration of 25 ppm.3. The C12 straight-chain amine and its corresponding amide produced similar inhibition and were much more potent than either the corresponding C12 phosphonate or a C12 branched-chain amine.4. Inhibition of the Δ24-sterol reductase system was exhibited by all four amines, but not by the amide or phosphonate, in the following order of activity: C12 branched-ehain amine > C12 straight-chain amine > C14 amine > C16 amine.5. The C12 branched amine also blocked the C-24(28)-dehydrogenase system in the conversion of sitosterol to fucosterol, the initial step in sitosterol dealkylation. |
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