Acylation of lysoglycerophospholipids by adrenal membranes |
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| Affiliation: | 1. School of Social Work, Florida Atlantic University, 777 Glades Road, Boca Raton, FL 33431, United States;2. School of Social Work, Cleveland State University, 2121 Euclid Ave, Cleveland, OH 44115, United States;3. Department of Mathematics, Cleveland State University, 2121 Euclid Ave, Cleveland, OH 44115, United States |
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| Abstract: | - 1.1. Substantial differences were found in the acyi donor and lyso-acceptor specificities among subcellular membranes and with respect to different regions of the adrenal gland.
- 2.2. In the presence of Mg2+-ATP and CoASH, adrenal microsomes were actively transferring arachidonate to lysophospholipids with acyl acceptor specificity in the order: 1-acyl-GPI > 1-acyl-GPC > 1-acyl-GP. However, when oleoyl-CoA was used, acyi acceptor specificity for the microsomal transferases was in the order: 1-acyl-GPC > 1-acyl-GP > 1-acyl-GPI.
- 3.3. Mitochondrial membranes had very low acyi transfer activity and they preferred 1-acyl-GPC over other lyso-acceptors.
- 4.4. The chromamn granules were apparently lacking this type of activity.
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