Ribosomal RNA synthesis in liver of adrenalectomized rats after partial hepatectomy |
| |
| Affiliation: | 1. Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, United States;2. Department of Pediatrics, Division of Hematology-Oncology, Baylor College of Medicine, Houston, TX, United States;3. Texas Children''s Hospital William T Shearer Center for Human Immunobiology, Houston, TX, United States;4. Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, United States;1. Science for Life Laboratory, Division of Genome Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden;2. Genomic Instability Group, Spanish National Cancer Research Centre (CNIO), Madrid 28029, Spain |
| |
| Abstract: | The ribosome formation in four experimental groups: normal, adrenalectomized, partially hepatectomized and adrenalectomized — partially hepatectomized rats was studied. Ribosomal RNA was labelled for different intervals and the transfer of the radioactivity from 45 S pre-rRNA through the nucleolar pre-rRNA and rRNA pools into cytoplasmic 28S and 18S rRNA was followed. The results show that there are at least two ways of positive control of rRNA synthesis, one of them being glucocorticoid-dependent. The acceleration of the pre-rRNA processing through the shortest maturation pathway in regenerating liver is reduced in the absence of the hormone. Glucocorticoids do not influence nucleo-cytoplasmic rRNA transport. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
