Glucosyl and galactosyl transferase activities of diabetic (db/db) and obese (ob/ob) mice kidneys |
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| Affiliation: | 1. Department of Obstetrics and Gynecology, Centre Hospitalier Universitaire de Sherbrooke, University of Sherbrooke, Sherbrooke, QC;2. Division of Nephrology, Centre Hospitalier Universitaire de Sherbrooke, University of Sherbrooke, Sherbrooke, QC;3. Department of Ergotherapy, University of Sherbrooke, Sherbrooke, QC;4. Division of Internal Medicine, Centre Hospitalier Universitaire de Sherbrooke, University of Sherbrooke, Sherbrooke, QC;1. Optics and Photonics Group, Institute of Physics, Federal University of Mato Grosso do Sul, Campo Grande, MS 79070-900, Brazil;2. Bioinorganic and Porphyrinoid Materials Laboratory, Department of Chemistry, Federal University of Santa Maria, Santa Maria, RS 97105-900, Brazil;3. Faculty of Exact Sciences and Technology, Federal University of Grande Dourados, CP 533, Dourados, MS 79804-970, Brazil;1. Aberdeen Cardiovascular & Diabetes Centre, School of Medicine, Medical Sciences and Nutrition, Aberdeen, UK;2. Radcliffe Department of Medicine, University of Oxford, Oxford, UK;3. Institute of Cardiovascular and Metabolic Sciences, School of Biological Sciences, University of Reading, Reading, UK;4. Katharine Dormandy Haemophilia and Thrombosis Centre Royal Free Hospital, London, UK |
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| Abstract: | - 1.1. Glucosyl and galactosyl activities were determined in kidney cortex tissue prepared from two strains of mice, genetically diabetic and obese mice.
- 2.2. These activities were measured as a function of ageing between 6 weeks and 13 months.
- 3.3. For both strains glucosyl transferase activity was shown to increase with respect to ageing whereas galactosyl transferase activity decreased at the same time.
- 4.4. These changes of enzymatic activities would suggest that a smaller increase of hydroxylysine-linked glycans than expected was observed under these pathological conditions.
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