Evaluation of the true precocious puberty rats induced by neonatal administration of Danazol: Therapeutic effects of nourishing "Yin"- removing "Fire" Chinese herb mixture |
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| Authors: | Zhanzhuang?Tian Hong?Zhao Yan?Sun Depei?Cai Email author" target="_blank">Boying?ChenEmail author |
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| Institution: | (1) Department of Neurobiology and Integrative Medicine, Shanghai Medical College of Fudan University (Formerly Shanghai Medical University), 138 Yi-Xue-Yuan Road, P.O. Box 291, 200032 Shanghai, P. R. China;(2) Children's Hospital of Fudan University, 183 Feng-Lin Road, 200032 Shanghai, P. R. China |
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| Abstract: | Background Nourishing "Yin"-Removing "Fire" Chinese Herb Mixture, a traditional herb-based formulation, has been successfully used for
the management of idiopathic true precocious puberty (IPP) for more than thirty years. Precocious puberty rat model by neonatal
administration of Danazol was used to investigate the effects of the herb mixture on the advanced sexual development of the
rats, and the expression of hypothalamic gonadotropin-releasing hormone (GnRH), which is the important regulator for the hypothalamus-pituitary-gonadal
axis, particularly at puberty. |
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