Genome-scale reconstruction of the metabolic network in Staphylococcus aureus N315: an initial draft to the two-dimensional annotation |
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Authors: | Scott?A?Becker Email author" target="_blank">Bernhard???PalssonEmail author |
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Institution: | (1) Department of Bioengineering, University of California, La Jolla, San Diego, USA |
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Abstract: | Background Several strains of bacteria have sequenced and annotated genomes, which have been used in conjunction with biochemical and
physiological data to reconstruct genome-scale metabolic networks. Such reconstruction amounts to a two-dimensional annotation
of the genome. These networks have been analyzed with a constraint-based formalism and a variety of biologically meaningful
results have emerged. Staphylococcus aureus is a pathogenic bacterium that has evolved resistance to many antibiotics, representing a significant health care concern.
We present the first manually curated elementally and charge balanced genome-scale reconstruction and model of S. aureus' metabolic networks and compute some of its properties. |
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