INSERM/UPVM 421, Plasticité cellulaire et thérapeutique, Faculté de Médecine, 94010 Créteil cedex France. oliveira@im3.inserm.fr
Abstract:
Background
Gliomas are "intraparenchymally metastatic" tumors, invading the brain in a non-destructive way that suggests cooperation
between glioma cells and their environment. Recent studies using an engineered rodent C6 tumor cell line have pointed to mechanisms
of invasion that involved gap junctional communication (GJC), with connexin 43 as a substrate. We explored whether this concept
may have clinical relevance by analyzing the participation of GJC in human glioblastoma invasion.