Construction and validation of the APOCHIP,a spotted oligo-microarray for the study of beta-cell apoptosis期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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Construction and validation of the APOCHIP,a spotted oligo-microarray for the study of beta-cell apoptosis

Authors:	Email author" target="_blank">Nils?E?Magnusson Email author Alessandra?K?Cardozo Mogens?Kruh?ffer Decio?L?Eizirik Torben?F??rntoft Jens?L?Jensen

Institution:	1.Molecular Diagnostic Laboratory, Department of Clinical Biochemistry,Aarhus University Hospital,Denmark;2.Department of Theoretical Statistics, Department of Mathematical Sciences,Aarhus University,Denmark;3.Laboratory of Experimental Medicine,Université Libre de Bruxelles,Brussels,Belgium

Abstract:	Background Type 1 diabetes mellitus (T1DM) is a autoimmune disease caused by a long-term negative balance between immune-mediated beta-cell damage and beta-cell repair/regeneration. Following immune-mediated damage the beta-cell fate depends on several genes up- or down-regulated in parallel and/or sequentially. Based on the information obtained by the analysis of several microarray experiments of beta-cells exposed to pro-apoptotic conditions (e.g. double stranded RNA (dsRNA) and cytokines), we have developed a spotted rat oligonucleotide microarray, the APOCHIP, containing 60-mer probes for 574 genes selected for the study of beta-cell apoptosis.

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