LEEP术联合保妇康栓治疗CIN合并高危型HPV持续感染的临床疗效分析

目的 观察宫颈电环切除术(LEEP术)联合保妇康栓治疗宫颈上皮内瘤变(CIN)合并高危型人乳头瘤病毒(HPV)持续感染的疗效.方法 158例病例随机分为两组,对照组79例,治疗组79例.治疗组患者在LEEP术后于阴道内放置保妇康栓,对照组未放置任何药物.观察两组患者宫颈创面愈合时间、术后并发症的发生情况、CIN消退及高危型HPV持续感染的情况.结果 两组患者官颈创面愈合时间、并发症发生情况比较差异无统计学意义(P＞0.05)；而CIN消退差异有统计学意义(P＜0.05)；高危型HPV持续感染率差异有统计学意义(P＜0.01).结论 LEEP术联合保妇康栓治疗CIN合并高危型HPV持续感染疗效满意,是较为理想的方法.

Evaluation of LEEP combined with Baofukang suppository in the treatment of CIN and persistent infection of high risk HPV

Objective To observe the effect of the loop electrosurgical excision procedure （LEEP） combined with Baofukang suppository in cervical intraepithelial neoplasia （CIN） and persistent infection of high risk human papillomavirus （HRHPV ）. Methods 158 patients were randomly divided into two groups ： control group （ n = 79） and treatment group （ n = 79 ）. Baofukang suppository was placed into the vagina after LEEP in the treatment group. The healing time, post operative complications, the regression rate of CIN and persistent infection of HR-HPV were observed in the two groups. Results There were no significant differences in the healing time and post operative complications （ P 〉 0.05 ）, but there were significant differences in the regression rate of CIN and persistent infection rate of HR-HPV between two groups （P 〈 0.05 and P 〈 0.01 respectively）. Conclusion LEEP combined with Baofukang suppository is an effective method for treatment of CIN and persistent infection of HR-HPV with satisfactory effects.