Functional cerebral activity of an analogue of serotonin formed in situ |
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| Affiliation: | 1. School of Life Sciences, Nantong University, Nantong 226019, People’s Republic of China;2. Jiangsu Key Laboratory for Food Quality and Safety-State Key Laboratory Cultivation Base of Ministry of Science and Technology, Institute of Plant Protection, Jiangsu Academy of Agricultural Sciences, Nanjing 226019, People’s Republic of China;1. Ministry of Agriculture Key Laboratory of Molecular Biology of Crop Pathogens and Insects, Institute of Insect Sciences, Zhejiang University, Hangzhou, China;2. Department of Entomology, College of Agriculture, South China Agricultural University, Guangzhou, China;3. Neuroscience Research Institute and Department of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, CA 93106, USA;1. Université du Québec à Montréal, Département des sciences biologiques, Montréal, QC H2X 1Y4, Canada;2. University of Arizona, Department of Ecology and Evolutionary Biology, PO Box 210088, Tucson, AZ 85721, United States;1. IFAPA – Centre ‘Alameda del Obispo’, Junta de Andalucía, Córdoba, Spain;2. CEIGRAM-AgSystems, Universidad Politécnica de Madrid, Madrid, Spain;3. Departamento de Agronomía, Universidad de Córdoba, Córdoba, Spain;1. Department of Biological Sciences, Bowling Green State University, Bowling Green, OH, U.S.A.;2. J. P. Scott Center for Neuroscience, Mind and Behavior, Bowling Green State University, Bowling Green, OH, U.S.A.;3. Department of Psychology, Bowling Green State University, Bowling Green, OH, U.S.A.;4. School of Biological Sciences, University of Nebraska-Lincoln, U.S.A. |
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| Abstract: | Reduction of the serotonin content of the brain of rats (specifically in the medial raphe nucleus) by various means results in spontaneous increase of adrenal tyrosine hydroxylase activity. This neurally mediated induction is attenuated by appropriate administration of the serotonin precursor 5-hydroxytryptophan to the animals, along with carbidopa (Quik and Sourkes, J. Neurochem.28, 137, 1977). In the present work adrenal tyrosine hydroxylase was induced by giving rats either the neurotoxin 5,7-dihydroxytryptamine (injected into the cerebral ventricles) or the monoamine depletor reserpine (given intraperitoneally). Other rats received alpha-methyltryptophan. This amino acid causes a marked decline of the serotonin content of the brain, but gives rise to relatively large amounts of alpha-methylserotonin in that organ (Roberge et al., Neuropharmacology11, 197, 1972). Alpha-methyltryptophan had no effect on adrenal tyrosine hydroxylase activity but, when it was given with dihydroxytryptamine or reserpine, it prevented the induction of adrenal tyrosine hydroxylase that otherwise occurred. The results are discussed in relation to the effect of alpha-methyltryptophan on the content of indoles (tryptophan, serotonin, 5-hydroxyindoleacetic acid, alpha-methyltryptophan, alpha-methylserotonin) in the plasma and brain, as detected by HPLC. It is concluded that alpha-methylserotonin can functionally replace cerebral serotonin, at least in relation to the transneuronal regulation of adrenal tyrosine hydroxylase activity. |
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