Circadian Variation of Cyclic AMP in the Rat Pineal Gland |
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Authors: | Masahiko Mikuni Yoshiro Saito Tsukasa Koyama Itaru Yamashita |
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Affiliation: | Department of Psychiatry and Neurology, Hokkaido University School of Medicine, North 15 West 7, Kita-Ku, Sapporo, Hokkaido, Japan |
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Abstract: | Abstract: This study was carried out to investigate circadian variation of cyclic AMP contents in the rat pineal glands, using the high-energy microwave radiation technique. The pattern of cyclic AMP concentration in the pineal gland showed a distinct circadian variation, with the maximum level at 0200 and the lowest at 1400. The administration of propranolol completely blocked the dark-induced increase in the pineal cyclic AMP level at 0200, and the administration of isoproterenol induced a threefold, rapid increase in the cyclic AMP level at 1400, although it did not change the level at 0200. |
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Keywords: | Circadian variation Cyclic AMP Rat pineal gland Microwave radiation Isoproterenol Propranolol |
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