Metabolic conversion of 24-methyl-Delta25-cholesterol to 24-methylcholesterol in higher plants |
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| Authors: | Takahashi Kyoko Nasu Kozue Mashino Tadahiko Morisaki Masuo Hara Noriyuki Fujimoto Yoshinori |
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| Institution: | Kyoritsu University of Pharmacy, Shibakoen, Tokyo 105-8512, Japan. takahashi-ky@kyoritsu-ph.ac.jp |
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| Abstract: | Feeding of chemically synthesized 27-13C]codisterol (27-13C]2), 27-13C]24-epicodisterol (27-13C]3), 23,24-2H2]codisterol (23,24-2H2]2), and 26,27-2H6]24-methyldesmosterol (26,27-2H6]8) to Oryza sativa cell cultures, followed by MS and NMR analysis of the biosynthesized dihydrobrassicasterol (9)/campesterol (10), revealed that both (24R)- and (24S)-epimers of 24-methyl-Delta25-cholesterol (2/3) were converted to 9 and 10 via the common intermediate 24-methyldesmosterol (8). |
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