首页 | 本学科首页   官方微博 | 高级检索  
     


Age-related changes of glucose metabolism in rat cerebral cortex with reference to glucose-derived amino acids
Authors:Hiroyuki Matsumoto  Masaharu Ito  Susumu Kikuchi  Masato Edamura
Affiliation:(1) The First Department of Internal Medicine, Sapporo Medical College, South 1 West 16, 060 Sapporo, Hakkaido, Japan
Abstract:The parietal cortical slices obtained from 8 week-old (young) and 78 week-old (middle-aged) male Wistar rats were incubated withd-[U-14C]glucose in oxygensaturated Gey's balanced salt solution. Subsequently, the radioactivities of liberated CO2 and glucose-derived amino acids (alanine, aspartate, GABA, glutamate and glutamine) obtained from the slices were measured. In the middle-aged rats as compared to the young rats, the amount of radioactivity of CO2 (P<0.01) and glutamate (P<0.05) showed a significant raduction with glutamine unchanged, while that of alanine (P<0.01), aspartate (P<0.05) and GABA (P<0.05) increased significantly. The results indicate that with advancing age the overall glucose oxidation in the cerebral cortex declines but the metabolic pathway to form amino acids is not uniformly suppressed. Therefore, the above characteristic glucose metabolism could be related to the development of heterogeneous enzyme activities associated with aging in the brain.
Keywords:
本文献已被 SpringerLink 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号