Flavonols and 4-thioflavonols as potential acetylcholinesterase and butyrylcholinesterase inhibitors: Synthesis,structure-activity relationship and molecular docking studies |
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Institution: | 1. Department of Molecular Biology and Genetics, Faculty of Arts and Sciences, Mus Alparslan University, Mus, 49250, Turkey;2. Agri Ibrahim Cecen University, Vocational School of Health Services, Department of Medical Services and Techniques, Agri, 04100, Turkey;3. Vocational School of Technical Sciences, Mus Alparslan University, Mus, 49250, Turkey;4. Atatürk University, Science Faculty, Chemistry Department, Erzurum, 25240, Turkey |
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Abstract: | To explore new scaffolds for the treat of Alzheimer’s disease appears to be an inspiring goal. In this context, a series of varyingly substituted flavonols and 4-thioflavonols have been designed and synthesized efficiently. All the newly synthesized compounds were characterized unambiguously by common spectroscopic techniques (IR, 1H-, 13C NMR) and mass spectrometry (EI-MS). All the derivatives (1–24) were evaluated in vitro for their inhibitory potential against cholinesterase enzymes. The results exhibited that these derivatives were potent selective inhibitors of acetylcholinesterase (AChE), except the compound 11 which was selective inhibitor of butyrylcholinesterase (BChE), with varying degree of IC50 values. Remarkably, the compounds 20 and 23 have been found the most potent almost dual inhibitors of AChE and BChE amongst the series with IC50 values even less than the standard drug. The experimental results in silico were further validated by molecular docking studies in order to find their binding modes with the active pockets of AChE and BChE enzymes. |
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Keywords: | Flavonoids Flavonols 3-hydroxyflavones 4-thioflavonols Sulfur compounds Cholinesterases AChE/BChE inhibitors Molecular docking studies |
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