A critical comparison of different residence time measures in aneurysms |
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| Affiliation: | 1. Center for Ecosystem Science and Society, Northern Arizona University, Flagstaff, AZ 86011, USA;2. School of Earth Sciences and Environmental Sustainability, Northern Arizona University, Flagstaff, AZ 86011, USA;3. Department of Civil Engineering, Construction Management, and Environmental Engineering, Northern Arizona University, Flagstaff, AZ 86011, USA;4. Environmental Sciences Division, Oak Ridge National Laboratory, Oak Ridge, TN 37831, USA;5. Department of Atmospheric Sciences, Colorado State University, Fort Collins, CO 80523, USA;6. Pacific Northwest Research Station, USDA Forest Service, Corvallis, OR 97331, USA;7. Department of Ecology, Montana State University, Bozeman, MT 59717, USA;8. Southern Research Station, USDA Forest Service, Raleigh, NC 27606, USA;9. International Center for Climate and Global Change Research School of Forestry and Wildlife Sciences, Auburn University, Auburn, 36849 AL, USA;10. Department of Atmospheric and Oceanic Science, University of Maryland, College Park, MD 20742, USA;1. Department of Biomedical Engineering, The Ohio State University, Columbus, OH, USA;2. Division of Cardiovascular Medicine, The Ohio State University, Columbus, OH, USA;3. Division of Cardiovascular Surgery, Mayo Clinics, Rochester, Minnesota, USA;1. School of Mechanical Engineering, Tel Aviv University, Tel Aviv, Israel;2. Department of Biomedical Engineering, Tel Aviv University, Tel Aviv, Israel;3. Division of Cardiology, Tel Aviv Medical Center, Tel Aviv, Israel;4. Department of Mechanical Engineering, University of California, Berkeley, CA, USA;1. Mechanical Engineering Department, Northern Arizona University, Flagstaff, AZ, USA;2. Bioengineering Department, University of California, Berkeley, CA, USA |
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| Abstract: | Flow stagnation and residence time (RT) are important features of diseased arterial flows that influence biochemical transport processes and thrombosis. RT calculation methods are classified into Eulerian and Lagrangian approaches where several measures have been proposed to quantify RT. Each of these methods has a different definition of RT, and it is not clear how they are related. In this study, image-based computational models of blood flow in an abdominal aortic aneurysm and a cerebral aneurysm were considered and RT was calculated using different methods. In the Lagrangian methods, discrete particle tracking of massless tracers was used to calculate particle residence time and mean exposure time. In the Eulerian methods, continuum transport models were used to quantify RT using Eulerian RT and virtual ink approaches. Point-wise RT and Eulerian indicator RT were also computed based on measures derived from velocity. A comparison of these methods is presented and the implications of each method are discussed. Our results highlight that most RT methods have a conceptually distinct definition of RT and therefore should be utilized depending on the specific application of interest. |
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| Keywords: | Flow stagnation Hemodynamics Blood flow Thrombosis Transport |
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