Three-dimensional in vivo kinematics and finite helical axis variables of the ovine stifle joint following partial anterior cruciate ligament transection |
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| Affiliation: | 1. McCaig Institute for Bone & Joint Health, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada;2. Schulich School of Engineering, University of Calgary, Calgary, AB, Canada;3. Section of Orthopaedics, Department of Surgery, Foothills Hospital, Calgary, Alberta, Canada;4. Faculty of Kinesiology, University of Calgary, Calgary, AB, Canada;5. Bone & Joint Strategic Clinical Network, Alberta Health Services, AB, Canada;1. Humanitas University;2. Humanitas Clinical and Research Center;1. Department of Physical Therapy and Human Movements Sciences, Northwestern University, Chicago, IL, USA;2. Shirley Ryan AbilityLab, Chicago, IL, USA;3. Department of Physiology, Northwestern University, Chicago, IL, USA;4. Department of Biomedical Engineering, Northwestern University, Chicago, IL, USA;1. Heart Rhythm Services, Division of Cardiology, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada;2. British Columbia Children''s Hospital, Department of Pediatrics, University of British Columbia, Vancouver, British Columbia, Canada;3. Department of Medical Genetics, University of British Columbia, Victoria, British Columbia, Canada;4. Department of Medicine, Western University, London, Ontario, Canada;1. Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand;2. Department of Engineering Science, Faculty of Engineering, University of Auckland, Auckland, New Zealand;3. Auckland Bioengineering Institute, University of Auckland, Auckland, New Zealand;4. Radiology Department, Auckland District Health Board, New Zealand;1. Department of Urology and Renal Transplantation, Yokohama City University Medical Center, Yokohama, Japan;2. Department of Laboratory Medicine, Yokohama City University Medical Center, Yokohama, Japan;3. Department of Urology, Yokohama City University Graduate School of Medicine, Yokohama, Japan |
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| Abstract: | Partial anterior cruciate ligament (p-ACL) rupture is a common injury, but the impact of a p-ACL injury on in vivo joint kinematics has yet to be determined in an animal model. The in vivo kinematics of the ovine stifle joint were assessed during ‘normal’ gait, and at 20 and 40 weeks after p-ACL transection (Tx). Gross morphological scoring of the knee was conducted. p-ACL Tx creates significant progressive post-traumatic osteoarthritis (PTOA)-like damage by 40 weeks. Statistically significant increases for flexion angles at hoof-strike (HS) and mid-stance (MST) were seen at 20 weeks post p-ACL Tx and the HS and hoof-off (HO) points at 40 weeks post p-ACL-Tx, therefore increased flexion angles occurred during stance phase. Statistically significant increases in posterior tibial shift at the mid-flexion (MF) and mid-extension (ME) points were seen during the swing phase of the gait cycle at 40 weeks post p-ACL Tx. Correlation analysis showed a strong and significant correlation between kinematic changes (instabilities) and gross morphological score in the inferior-superior direction at 40 weeks post p-ACL Tx at MST, HO, and MF. Further, there was a significant correlation between change in gross morphological combined score (ΔGCS) and the change in location of the helical axis in the anterior direction (ΔsAP) after p-ACL Tx for all points analyzed through the gait cycle. This study quantified in vivo joint kinematics before and after p-ACL Tx knee injury during gait, and demonstrated that a p-ACL knee injury leads to both PTOA-like damage and kinematic changes. |
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| Keywords: | Kinematics Anterior cruciate ligament Post-traumatic osteoarthritis Knee joint Knee injury |
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