Numerical simulation of haemodynamics of the descending aorta in the non-diabetic and diabetic rabbits |
| |
| Institution: | 1. Key Laboratory of Biorheological Science and Technology, Ministry of Education, State and Local Joint Engineering Laboratory for Vascular Implants, Bioengineering College of Chongqing University, Chongqing, PR China;2. Shanghai East Hospital, Institute for Biomedical Engineering and Nano Science, Tongji University School of Medicine, Shanghai, PR China;3. Shanghai Jiao Tong University and Chiba University International Cooperative Research Center, School of Naval Architecture, Ocean and Civil Engineering, Shanghai Jiao Tong University, Shanghai, PR China;1. Department of Cardiovascular Surgery, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan;2. Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan;3. Department of Pathology, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan;1. Department of Aerospace and Mechanical Engineering, University of Notre Dame, Notre Dame, IN, USA;2. Department of Mechanical and Materials Engineering, Wright State University, Dayton, OH, USA;2. Key Laboratory for Biomechanics and Mechanobiology of the Ministry of Education, School of Biological Science and Medical Engineering, Beihang University, Beijing, People’s Republic of China;3. SuperComputing Applications and Innovation Department – SCAI, CINECA, Milan, Italy;4. IBFM, Research National Council, Milan, Italy;1. Department of Cardiology, Biomedical Engineering, Erasmus MC, Rotterdam, The Netherlands;2. Laboratory of Biological Structure Mechanics (LaBS), Department of Chemistry, Materials and Chemical Engineering “Giulio Natta”, Politecnico di Milano, Milan, Italy;4. FEops NV, Ghent, Belgium |
| |
| Abstract: | Diabetes mellitus (DM) is a predisposing risk factor leading to macrovascular diseases. Changes in haemodynamics of the diabetic aortas remain largely unclear and relevant computational analyses are lacking in the literature. Ten adult rabbits (1.6–2.2 kg) were collected and the type I diabetic rabbit model was induced by injection of alloxan. A total of five control and five diabetic rabbit aortas were considered for subsequent numerical simulation. The CT scanning was performed to reconstruct three-dimensional model of the individual rabbit descending aorta. The flow velocity waveforms were measured by ultrasound machine and were set to be the inlet boundary conditions. The reconstructed aortas were then imported into ANSYS to perform mesh generation and computational analysis. Results showed that the distributions of haemodynamic indicators time-averaged wall shear stress (TAWSS), oscillating shear index (OSI) and transverse wall shear stress (transWSS) in the non-diabetic rabbit aortas were similar to those in the diabetic rabbit aortas. However, the mean values of TAWSS and transWSS in the non-diabetic rabbit aortas were significantly higher than those values in the diabetic rabbit aortas (TAWSS: p = 0.04; transWSS: p = 0.02). The back of right renal artery tended to have high OSI in both the non-diabetic and the diabetic rabbit aortas. Notably, the regions with high OSI tended to have intense disturbed flow and low TAWSS in the most diabetic rabbit aortas. The results suggest that diabetes leads to changes in haemodynamic parameters in the rabbit aortas. In particular, the lower TAWSS and the higher OSI within the diabetic aortas may further contribute to aortic wall remodeling. |
| |
| Keywords: | Diabetes mellitus Descending aorta Haemodynamics Wall shear stress Finite element method |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
