Lithocarols A-F,six tenellone derivatives from the deep-sea derived fungus Phomopsis lithocarpus FS508 |
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| Institution: | 1. State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Open Laboratory of Applied Microbiology, Guangdong Institute of Microbiology, Guangzhou 510070, China;2. College of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China;3. Key Laboratory of Plant Resources Conservation and Sustainable Utilization, Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, China;1. G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far-Eastern Branch of the Russian Academy of Sciences, Prospect 100-letiya Vladivostoku 159, Vladivostok 690022, Russian Federation;2. Far Eastern Federal University, Suhanova Street 8, Vladivostok 690950, Russian Federation;3. Institute of Chemistry, Far-Eastern Branch of the Russian Academy of Sciences, Prospect 100-letiya Vladivostoku 159, Vladivostok 690022, Russian Federation;1. Eskitis Institute for Drug Discovery, Griffith University, Brisbane, QLD 4111, Australia;2. Queensland Herbarium, Brisbane Botanic Gardens Mt Coot-tha, Brisbane, QLD 4066, Australia;1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, Yunnan, People''s Republic of China;2. University of Chinese Academy of Sciences, Beijing 100049, People''s Republic of China;3. College of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing 400054, People''s Republic of China |
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| Abstract: | Lithocarols A-F (1–6) possessing novel highly-oxygenated isobenzofuran core, together with a related known compound isoprenylisobenzofuran A (7) were isolated from the marine-derived fungus Phomopsis lithocarpus FS508. Among them, lithocarols A-E (1–5) represent the first examples of poly-ketal derivatives in tenellone family. The structures for all these compounds were fully elucidated by spectroscopic analysis, X-ray diffraction, and electronic circular dichroism calculations. Their cytotoxic assay disclosed that compounds 1–4 displayed moderate growth inhibitory effect against four human tumor cell lines with the IC50 values ranging from 10.5 to 38.7 μM. |
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| Keywords: | Deep-sea derived fungus Tenellone derivatives Lithocarols Cytotoxicity |
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