Anti-cancer activity of the cell membrane-permeable phytic acid prodrug |
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| Affiliation: | 1. Research Center for Health and Nutrition, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China;2. Teaching and Experimental Center, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China;3. Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China;4. Global Pharmaceutical Research and Development, Hospira Inc., 1776 North Centennial Drive, McPherson, KS 67460, USA;5. Pharmacy Department, Shanghai TCM-Integrated Hospital, Shanghai 200082, China |
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| Abstract: | Phytic acid (IP6) is an ingredient in cereals and legumes, and limited amounts of this compound are considered to enter the cell and exert anti-cancer effects. These effects have been seen by studying cells treated with around 1–5 mM IP6. However, such a large amount of IP6 chelates metals and changes the pH in cell culture medium. To overcome this problem, we synthesized a prodrug of IP6 (Pro-IP6) and elucidated generation of IP6 from Pro-IP6 in cells. Cellular experiments using Pro-IP6 demonstrated selective anti-cancer effects including apoptosis and inhibition of Akt activation. Furthermore, an in vivo study using mice with adult T-cell leukemia also showed that Pro-IP6 reduced the size of the cancer. Taken together, Pro-IP6 is a useful biological tool and may lead to development of new anti-cancer drugs. |
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| Keywords: | Phytic acid IP6 Prodrug Anti-cancer activity Apoptosis Akt Adult T-cell leukemia |
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